![]() ![]() The duration of effect is approximatelyģ0–60 minutes. The onset of effect is withinĥ–10 minutes after administration. MUSE should beĪdministered as needed to achieve an erection. MUSE is a transurethral delivery system available in 4ĭosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg. Success rates for sexual intercourse compared with similarly administered Studies that established benefit demonstrated improvements in MUSE is indicated for the treatment of erectileĭysfunction. MUSE is available in 4 dosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg. There are no other active agents or excipients in MUSE. The inactive ingredient in MUSE is polyethylene glycol 1450, USP. Its solubility at 35☌ is 8000 mcg per 100 mL double-distilled water. The structural formula of alprostadil is represented below:Īlprostadil is a white to off-white crystalline powder with a melting point between 115° and 116☌. The chemical name for alprostadil is prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-(11α,13E,15S)-(1R,2R,3R)-3-hydroxy-2-5-oxocyclopentane heptanoic acid, and the molecular weight is 354.49. The active ingredient in MUSE is alprostadil, which is chemically identical to the naturally occurring eicosanoid, prostaglandin E 1 (PGE 1). Each MUSE system is packaged in an individual foil pouch.įigure 1: Diagram of the MUSE Trans urethral System The components of the delivery system are constructed of medical grade polypropylene. The pellet containing alprostadil is delivered by depressing the applicator button (see Figure 1). MUSE is administered by inserting the applicator stem into the urethra after urination. Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet ( micro-suppository measuring 1.4 mm in diameter by 3 mm or 6 mm in length) that resides in the tip of a translucent hollow applicator. MUSE® (alprostadil) is a single-use, medicated transurethral system for the delivery of alprostadil to the male urethra. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Muse. Tell the doctor if you have any side effect that bothers you or that does not go away. vaginal burning or itching (in female partners).The most common side effects of Muse include: Get medical help right away, if you have any of the symptoms listed above. painful or prolonged erection lasting 4 or more hours.swelling of your face, lips, tongue, or throat,.Muse may cause serious side effects including: What are the possible side effects of Muse? It is not known if Muse is safe and effective in children. Muse belongs to a class of drugs called Prostaglandins, Genitourinary. Muse may be used alone or with other medications. Muse is a prescription medicine used to treat the symptoms of Erectile Dysfunction. ![]() Find Lowest Prices on What is Muse and how is it used?
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